Article
Biomarker-informed CSF proteomics reveals ENPP2–LPA lipid signaling associated with Alzheimer’s disease
2026-07-10
Abstract excerpt
<h4>Background</h4> Alzheimer’s disease (AD) involves complex molecular alterations in the cerebrospinal fluid (CSF) proteome, yet the links between these protein changes and hallmark AD pathology remain incompletely defined. We investigated the relationship between the CSF proteome with CSF biomarkers of Alzheimer’s disease (AD). <h4>Methods</h4> CSF was collected in 500 individuals of non-Hispanic white, Afric...
Topics
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- Advanced Proteomics Techniques and Applications
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Dementia and Cognitive Impairment Research
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
Identifiers and source
- Literature Corpus work
- 7ee0be01-bff6-5e53-9050-3f419e843daf
- DOI
- 10.64898/2026.07.08.26357565