In vitro and in vivo disease models of cardiac amyloidosis: progress, pitfalls, and potential.

Abstract excerpt

Amyloid light chain (AL) and transthyretin amyloidosis (ATTR)-induced cardiomyopathy are life-threatening protein misfolding disorders characterized by amyloid fibril deposition in the heart, which significantly impairs cardiac function. The lack of representative disease models has impeded progress in understanding the underlying mechanisms and hindered the discovery and development of specific biomarkers and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid Neuropathies, Familial
• Share to Cardiomyopathies