Article

Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production

2020-07-19

Abstract excerpt

Mammals have two insulin-like growth factors (IGF) that are key mediators of somatic growth, of tissue differentiation and cellular responses to stress. Thus, the mechanisms that regulate the bioavailability of IGFs are important in both normal and aberrant development. IGF-I levels are primarily controlled via the growth hormone-IGF axis, in response to nutritional status, and also reflect metabolic diseases and...

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Literature Corpus work: 2e8ba7a5-b5dc-5111-9813-fe62029f7e2f
DOI: 10.20944/preprints202007.0432.v1

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