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Article

GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.

Molecular biology of the cell - 1 Oct 2007

Wanderling Sherry, Simen Birgitte B, Ostrovsky Olga, Ahmed Noreen T, Vogen Shawn M, Gidalevitz Tali, Argon Yair

Abstract excerpt

Because only few of its client proteins are known, the physiological roles of the endoplasmic reticulum chaperone glucose-regulated protein 94 (GRP94) are poorly understood. Using targeted disruption of the murine GRP94 gene, we show that it has essential functions in embryonic development. grp94-/- embryos die on day 7 of gestation, fail to develop mesoderm, primitive streak, or proamniotic cavity. grp94-/- ES...

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Identifiers

PMID: 17634284
DOI: 10.1091/mbc.e07-03-0275
PMCID: PMC1995707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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