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Article

A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production.

Endocrinology - 1 May 2016

Marzec Michal, Hawkes Colin P, Eletto Davide, Boyle Sarah, Rosenfeld Ron, Hwa Vivian, Wit Jan M, van Duyvenvoorde Hermine A, Oostdijk Wilma, Losekoot Monique, Pedersen Oluf, Yeap Bu Beng, Flicker Leon, Barzilai Nir, Atzmon Gil, Grimberg Adda, Argon Yair

Abstract excerpt

IGFs are critical for normal intrauterine and childhood growth and sustaining health throughout life. We showed previously that the production of IGF-1 and IGF-2 requires interaction with the chaperone glucose-regulated protein 94 (GRP94) and that the amount of secreted IGFs is proportional to the GRP94 activity. Therefore, we tested the hypothesis that functional polymorphisms of human GRP94 affect IGF...

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Identifiers

PMID: 26982636
DOI: 10.1210/en.2015-2058
PMCID: PMC4870884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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