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NHA2 promotes cyst development in an <i>in vitro</i> model of polycystic kidney disease

2018-07-07

Abstract excerpt

<h4>Summary</h4> Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2 encoding polycystin-1 (PC1) and polycystin-2 (PC2), respectively. The molecular pathways linking polycystins to cyst development in ADPKD are still unclear. Intracystic fluid secretion via ion transporters and channels plays a crucial role in cyst expansion in ADPKD. Unexpectedly, we observed significan...

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Literature Corpus work
2e855394-c123-510e-bcb1-64b7d9a54caa
DOI
10.1101/364679
Open publication

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