Article

Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to Hypertension

2024-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Cardiovascular complications are the most common cause of mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Hypertension is seen in 70% of patients by the age of 30 prior to decline in kidney function. The natriuretic peptides (NPs), atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), are released by cardiomyocytes in response to membrane stretch,...

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Literature Corpus work: 48e9f249-967d-5424-b9cb-7553af55eaeb
DOI: 10.1101/2024.01.02.573922

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