Article

Adult Neuronal Expression of the Alzheimer Risk Protein CD2AP is Enriched in NGF-Responsive Basal Forebrain Neurons, where it Collocates with Rab-5 Endosomes

2024-07-24

Abstract excerpt

Genome-wide association studies (GWAS) with multiple human populations have uncovered single nucleotide variants of the CD2AP gene locus that are associated with Alzheimer’s Disease (AD) risk. However, the role of CD2AP in AD pathogenesis remains unknown. In adult PNS neurons, previous work demonstrated that CD2AP functions as a docking-scaffold/adaptor protein coordinator of nerve growth factor (NGF) trophic sig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e73c131-c15c-558e-a151-217ce746ad46
DOI: 10.1101/2024.07.24.604961

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adult Neuronal Expression of the Alzheimer Risk Protein CD2AP is Enriched in NGF-Responsive Basal Forebrain Neurons, where it Collocates with Rab-5 EndosomesDOI 10.1101/2024.07.24.604961Read

cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and ProteostasisSemantic proximity Read

Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity.Semantic proximity Read

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer’s diseaseSemantic proximity Read

CD2AP deficiency aggravates Alzheimer's disease phenotypes and pathology through p38 MAPK activation.Semantic proximity Read

The Alzheimer’s disease risk gene CD2AP functions in dendritic spines by remodelling F-actinSemantic proximity Read

The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-ActinSemantic proximity Read

Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson’s disease-linked genesSemantic proximity Read

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s diseaseSemantic proximity Read

Cell type-specific biotin labeling <i>in vivo</i> resolves regional neuronal proteomic differences in mouse brainSemantic proximity Read

APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neuronsSemantic proximity Read

Revealing Notch-dependencies in synaptic targets associated with Alzheimer’s diseaseSemantic proximity Read

Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegenerationSemantic proximity Read