Article
Alzheimer's disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity.
Human molecular genetics - 7 Oct 2024
Pavešković Matea, De-Paula Ruth B, Ojelade Shamsideen A, Tantry Evelyne K, Kochukov Mikhail Y, Bao Suyang, Veeraragavan Surabi, Garza Alexandra R, Srivastava Snigdha, Song Si-Yuan, Fujita Masashi, Duong Duc M, Bennett David A, De Jager Philip L, Seyfried Nicholas T, Dickinson Mary E, Heaney Jason D, Arenkiel Benjamin R, Shulman Joshua M
Abstract excerpt
CD2-Associated protein (CD2AP) is a candidate susceptibility gene for Alzheimer's disease, but its role in the mammalian central nervous system remains largely unknown. We show that CD2AP protein is broadly expressed in the adult mouse brain, including within cortical and hippocampal neurons, where it is detected at pre-synaptic terminals. Deletion of Cd2ap altered dendritic branching and spine density, and...
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