Article

The Alzheimer’s disease risk gene CD2AP functions in dendritic spines by remodelling F-actin

2023-09-01

Abstract excerpt

CD2AP was identified as a genetic risk factor for late-onset Alzheimer’s disease (LOAD). However, how CD2AP contributes to LOAD synaptic dysfunction underlying AD memory deficits is unclear. We have shown that CD2AP loss-of-function increases β-amyloid (Aβ) endocytic production, but whether it contributes to synapse dysfunction is unknown. Because CD2AP is an actin-binding protein, it may also function in F-actin-...

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Literature Corpus work: 2755669d-c1b7-5618-bc2b-1d83d2388e7d
DOI: 10.1101/2023.08.31.555707

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