Article

Glial-specific and inducible full body C3 deficiency does not affect amyloid pathology in the AppNL-G-F mouse model of Alzheimer’s disease

2025-05-29

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer's disease (AD) is intricately linked with neuroinflammation, with the complement system, particularly C3, emerging as a critical player. However, research has been hampered by the reliance on classical germline C3 knockout and APP overexpressing mouse models, which do not allow to study temporal and cell-specific C3 effects, and do not accurately reflect the comple...

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Literature Corpus work: 2e661db4-62d1-5a5c-9054-1a1e7455afde
DOI: 10.21203/rs.3.rs-6597252/v1

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