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Article

Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

15 Jan 2011

Abstract excerpt

BACKGROUND: Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine models of AD, Tg2576 and 3xTg. Previously, a genetic deficiency of C1q in the Tg2576 mouse model showed an accumulation of fibrillar plaques similar to the complement sufficient Tg2576, but...

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PMID: 21235806
DOI: 10.1186/1742-2094-8-4

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