Article

bMSI-CAST: a systematic method for next generation sequencing-based microsatellite instability detection in plasma cell-free DNA

2021-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Microsatellite instability (MSI) is a well-established prognostic and predictive biomarker in certain types of cancers. MSI detection using tumour tissue is often limited by the availability of specimens. Next generation sequencing (NGS)-based MSI detection in plasma cell-free DNA (cfDNA) is challenged by a much lower signal-to-noise ratio. We developed a highly accurate cfDNA MSI detection meth...

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Literature Corpus work: 2e641d59-1871-5828-9a65-9b1ab1db75d7
DOI: 10.1101/2021.02.22.432191

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