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Validation of Microsatellite Instability Detection Using a Comprehensive Plasma-Based Genotyping Panel

1 Dec 2019

Abstract excerpt

Abstract Purpose: To analytically and clinically validate microsatellite instability (MSI) detection using cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using Guardant360 was analytically validated according to established guidelines and clinically validated using 1,145 cfDNA samples for which tissue MSI status based on standard-of-care tissue testing was available. The landscape...

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PMID: 31383735
DOI: 10.1158/1078-0432.ccr-19-1324

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