Article

Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy

2023-02-06

Abstract excerpt

Essential epigenetic dependencies have become evident in many cancers. Based on the functional antagonism between BAF/SWI/SNF and PRC2 in SMARCB1 -deficient sarcomas, we and colleagues recently completed the clinical trial of the EZH2 inhibitor tazemetostat. However, the principles of tumor response to epigenetic therapy in general, and tazemetostat in particular, remain unknown. Using functional genomics of pati...

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Literature Corpus work: da408393-1678-52f2-9348-0482145b1e5d
DOI: 10.1101/2023.02.06.527192

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