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Article

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.

Blood advances - 12 Apr 2022

Xu Jane Jialu, Chalk Alistair M, Nikolic Iva, Simpson Kaylene J, Smeets Monique F, Walkley Carl R

Abstract excerpt

Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approach has only been modestly sensitizing and is also toxic to non-mutant-bearing wild-type cells. To explore potentially exploitable genetic interactions with spliceosome mutations, we combined data mining and functional screening for synthetic lethal interactions with an Srsf2P95H/+...

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Identifiers

PMID: 34464972
DOI: 10.1182/bloodadvances.2021004571
PMCID: PMC9006275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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