Article
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.
Blood - 12 Apr 2012
Thol Felicitas, Kade Sofia, Schlarmann Carola, Löffeld Patrick, Morgan Michael, Krauter Jürgen, Wlodarski Marcin W, Kölking Britta, Wichmann Martin, Görlich Kerstin, Göhring Gudrun, Bug Gesine, Ottmann Oliver, Niemeyer Charlotte M, Hofmann Wolf-Karsten, Schlegelberger Brigitte, Ganser Arnold, Heuser Michael
Abstract excerpt
Mutations in genes of the splicing machinery have been described recently in myelodysplastic syndromes (MDS). In the present study, we examined a cohort of 193 MDS patients for mutations in SRSF2, U2AF1 (synonym U2AF35), ZRSR2, and, as described previously, SF3B1, in the context of other molecular markers, including mutations in ASXL1, RUNX1, NRAS, TP53, IDH1, IDH2, NPM1, and DNMT3A. Mutations in SRSF2, U2AF1,...
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