Article

Targeting the PNN–Microglia Axis: Evidence for Exercise-Induced Central and Peripheral Anti-Inflammatory Reprogramming in Osteoarthritis

2025-12-09

Abstract excerpt

<title>Abstract</title> <p>Knee osteoarthritis (OA) is a leading cause of chronic pain and disability, yet the mechanisms linking central neuroinflammation to pain persistence remain poorly defined. This study identifies a novel perineuronal net (PNN)–microglia axis within the medial prefrontal cortex (mPFC) as a critical regulator of OA pain sensitization. Using a rat OA model, we demonstrate that high-intensity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e52ff43-b5fa-5437-bc29-cb1866dff868
DOI: 10.21203/rs.3.rs-8212616/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting the PNN–Microglia Axis: Evidence for Exercise-Induced Central and Peripheral Anti-Inflammatory Reprogramming in OsteoarthritisDOI 10.21203/rs.3.rs-8212616/v1Read

Distinct late-stage osteoarthritis profiles identified through NF-κB, TNF-α, and TGF-β–driven synovial inflammation and painSemantic proximity Read

Newly repopulated spinal cord microglia exhibit a unique transcriptome and correlate with pain resolutionSemantic proximity Read

Neuroinflammatory Biomarkers in Chronic Low Back Pain: Mechanisms, Clinical Evidence, and Translational ChallengesSemantic proximity Read

Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis.Semantic proximity Read

Leptin drives osteoarthritis pain through sensory neuron reprogramming independent of cartilage signalingSemantic proximity Read

Immunological Profiling in Knee Osteoarthritis: Treg Dysfunction as Key Driver of PainSemantic proximity Read

Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain MechanismsSemantic proximity Read

Differential expression of cerebrospinal fluid neuroinflammatory mediators depending on osteoarthritis pain phenotype.Semantic proximity Read

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J miceSemantic proximity Read

Transcriptional and cellular signatures of cortical morphometric similarity remodelling in chronic painSemantic proximity Read

Osteoarthritis pain. Recent advances and controversies.Semantic proximity Read

Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets.Semantic proximity Read