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Article

Neuroimmune Phenotyping as the Next Frontier in Chronic Pain Medicine for Musculoskeletal Back Pain.

Current pain and headache reports - 5 Sept 2026

Salman Samer G, Phadke Rohan A, Nair Adithya, Kumar Rahul, Momin Arbaz, Tavakkoli Alireza, Rizkalla James

Abstract excerpt

BACKGROUND: Chronic low back pain encompasses heterogeneous mechanical, neuropathic, nociplastic, and myofascial presentations that may reflect distinct neuroimmune mechanisms. We synthesized evidence linking these phenotypes to measurable biological features and clinically relevant treatment strategies. METHODS: We conducted a structured literature search of MEDLINE, Scopus, Web of Science, and the Cochrane...

Read the complete abstract on PubMed

Topics

Humans
Chronic Pain
Phenotype
Musculoskeletal Pain
Neuroimmunomodulation
Low Back Pain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers

Source

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Identifiers

PMID: 42700197
DOI: 10.1007/s11916-026-01561-w
PMCID: PMC13546305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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