Article

ILP4 and InR regulate Paclitaxel-induced hypersensitivity differently in <i>Drosophila</i> larvae

2025-09-12

Abstract excerpt

Paclitaxel (PTX), a chemotherapeutic that stabilizes microtubules, induces nociceptive hypersensitivity and sensory neuron damage in humans, mice, and flies. To enhance our basic understanding of PTX-induced effects we undertook a molecular/genetic dissection of PTX-induced nociceptive hypersensitivity. Larvae fed viable doses of PTX exhibited dose-dependent hypersensitivity to sub-noxious thermal stimuli. Hyperse...

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Literature Corpus work: 2e4cea81-c3a5-51c7-ac48-c93a76d4bf93
DOI: 10.1101/2025.09.12.675934

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