Article
A Chemotherapy-Induced Peripheral Neuropathy Model in Drosophila melanogaster.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Bhattacharya Martha R C
Abstract excerpt
Peripheral neuropathies are one of the largest categories of neurodegenerative diseases. To investigate their mechanisms, many in vitro and in vivo models can be employed. Here we present a protocol for the induction of chemotherapy-induced peripheral neuropathy (CIPN) in the Drosophila melanogaster (fruit fly) model system. Using a clinically relevant degeneration initiator, paclitaxel (taxol), it is possible to...
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