Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization.

Disease models & mechanisms - 10 May 2018

Im Seol Hee, Patel Atit A, Cox Daniel N, Galko Michael J

Abstract excerpt

Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin signaling, the functional locus of insulin signaling in diabetes-associated hypersensitivity remains obscure. Here, we used Drosophila nociception/nociceptive sensitization assays to investigate the role of Insulin receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendrites
Share to Diabetes Mellitus, Type 1
Share to Hyperalgesia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nociceptors

Share to Receptor Protein-Tyrosine Kinases

Share to Sensory Receptor Cells

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 29752280
DOI: 10.1242/dmm.034231
PMCID: PMC5992604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization.PMID 29752280Read ↗

ILP4 and InR regulate Paclitaxel-induced hypersensitivity differently in <i>Drosophila</i> larvaeSemantic proximity Read ↗

Duox mediates ultraviolet injury-induced nociceptive sensitization in Drosophila larvae.Semantic proximity Read ↗

Injury-induced cold sensitization in <i>Drosophila</i> larvae involves behavioral shifts that require the TRP channels Pkd2 and Brv1Semantic proximity Read ↗

Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD PathwaySemantic proximity Read ↗

Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in DrosophilaSemantic proximity Read ↗

Isolation and characterization of high-temperature-induced Dauer formation mutants in Caenorhabditis elegans.Semantic proximity Read ↗

A subpopulation of peripheral sensory neurons expressing the Mas-related G Protein-Coupled Receptor d (Mrgprd) generates pain hypersensitivity in painful diabetic neuropathySemantic proximity Read ↗

Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.Semantic proximity Read ↗

Peripheral straightjacket (α2δ Ca 2+ channel subunit) expression is required for neuropathic sensitization in DrosophilaSemantic proximity Read ↗

Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.Semantic proximity Read ↗

Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight.Semantic proximity Read ↗

Insulin-dependent maturation of newly generated olfactory sensory neurons after injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.