Peripheral straightjacket (α2δ Ca 2+ channel subunit) expression is required for neuropathic sensitization in Drosophila

Abstract excerpt

Nerve injury leads to devastating and often untreatable neuropathic pain. While acute noxious sensation (nociception) is a crucial survival mechanism and is conserved across phyla, chronic neuropathic pain is considered a maladaptive response owing to its devastating impact on a patient's quality of life. We have recently shown that a neuropathic pain-like response occurs in adult Drosophila . However, the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ion channel regulation and function
• Share to Ion Channels and Receptors
• Share to Pain Mechanisms and Treatments