Article

Cytomegaloviral determinants of CD8 <sup>+</sup> T cell programming and RhCMV/SIV vaccine efficacy

2020-10-01

Abstract excerpt

Simian immunodeficiency virus (SIV) insert-expressing, 68-1 Rhesus Cytomegalovirus (RhCMV/SIV) vectors elicit major histocompatibility complex (MHC)-E- and -II-restricted, SIV-specific CD8 + T cell responses, but the basis of these unconventional responses and their contribution to demonstrated vaccine efficacy against SIV challenge in the rhesus monkeys (RMs) has not been characterized. We demonstrate that these...

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Literature Corpus work: 2e3d732d-fd10-5a47-88f6-f58b4434b599
DOI: 10.1101/2020.09.30.321349

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