Article

Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy

2021-01-11

Abstract excerpt

Simian immunodeficiency virus (SIV) challenge of rhesus macaques (RMs) vaccinated with Rhesus Cytomegalovirus (RhCMV) vectors expressing SIV proteins (RhCMV/SIV) results in a binary outcome: stringent control and subsequent clearance of highly pathogenic SIV in ~55% of vaccinated RMs with no protection in the remaining 45%. Although previous work suggests that unconventionally restricted, SIV-specific, effector-me...

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Literature Corpus work: 31b66e94-c316-529b-9df5-3cd8de295d33
DOI: 10.1101/2021.01.11.426199

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