Article
In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome.
PLoS pathogens - 1 Nov 2020
Taher Husam, Mahyari Eisa, Kreklywich Craig, Uebelhoer Luke S, McArdle Matthew R, Moström Matilda J, Bhusari Amruta, Nekorchuk Michael, E Xiaofei, Whitmer Travis, Scheef Elizabeth A, Sprehe Lesli M, Roberts Dawn L, Hughes Colette M, Jackson Kerianne A, Selseth Andrea N, Ventura Abigail B, Cleveland-Rubeor Hillary C, Yue Yujuan, Schmidt Kimberli A, Shao Jason, Edlefsen Paul T, Smedley Jeremy, Kowalik Timothy F, Stanton Richard J, Axthelm Michael K, Estes Jacob D, Hansen Scott G, Kaur Amitinder, Barry Peter A, Bimber Benjamin N, Picker Louis J, Streblow Daniel N, Früh Klaus, Malouli Daniel
Abstract excerpt
Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal models using host-specific CMVs. Infection of rhesus macaques (RM) with rhesus CMV (RhCMV) has been established as a representative model for infection of humans with HCMV due to the close evolutionary relationships of both host and...
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