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Human cytomegalovirus UL18 prevents priming of MHC-E– and MHC-II–restricted CD8 + T cells

11 Oct 2024

Abstract excerpt

T cells that stringently control simian immunodeficiency virus (SIV) in rhesus macaques. These responses require deletion of eight RhCMV chemokine-like open reading frames (ORFs) that are conserved in human cytomegalovirus (HCMV). To determine whether HCMV encodes additional, nonconserved inhibitors of unconventional T cell priming, we inserted 41 HCMV-specific ORFs into a chemokine-deficient strain (68-1 RhCMV)....

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PMID: 39392895
DOI: 10.1126/sciimmunol.adp5216

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