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Article

Rhesus Cytomegalovirus-Specific CD8+ Cytotoxic T Lymphocytes Do Not Become Functionally Exhausted in Chronic SIVmac239 Infection.

Frontiers in immunology - 1 Jan 2020

Rosen Brandon C, Pedreño-Lopez Nuria, Ricciardi Michael J, Reed Jason S, Sacha Jonah B, Rakasz Eva G, Watkins David I

Abstract excerpt

CD8+ cytotoxic T lymphocytes (CTLs) exert potent antiviral activity after HIV/SIV infection. However, efforts to harness the antiviral efficacy of CTLs for HIV/SIV prophylaxis and therapy have been severely hindered by two major problems: viral escape and exhaustion. By contrast, CTLs directed against human cytomegalovirus (HCMV), a ubiquitous chronic herpesvirus, seldom select for escape mutations and remain...

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Source

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Identifiers

PMID: 32922404
DOI: 10.3389/fimmu.2020.01960
PMCID: PMC7457070

Genes

CCR7
CD28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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