Article

Alternative splicing and genetic variation of MHC-E: Implications for rhesus cytomegalovirus-based vaccines

2022-06-14

Abstract excerpt

<title>Abstract</title> <p>Rhesus cytomegalovirus (RhCMV)-based vaccination against Simian Immunodeficiency virus (SIV) elicits MHC-E-restricted CD8 + T cells that stringently control SIV infection in ~ 55% of vaccinated rhesus macaques (RM). However, it is unclear how accurately the RM model reflects HLA-E immunobiology in humans. Using long-read sequencing, we identified 16 Mamu-E isoforms and all Mamu-E splici...

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Literature Corpus work: baf5addc-30f9-5638-8d03-79fc1554751f
DOI: 10.21203/rs.3.rs-1633558/v1

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