Article

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

2020-10-02

Abstract excerpt

Strain 68-1 rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) antigens elicit CD8 + T cells that recognize peptide epitopes presented by major histocompatibility complex (MHC)-II and MHC-E molecules, instead of MHC-Ia, and are uniquely able to mediate stringent control and subsequent clearance of highly pathogenic SIV in ∼50% of vaccinated rhesus macaques (RMs). We show that th...

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Literature Corpus work: 4d059d3b-b9e0-579a-8ab7-fc70cd9dbf28
DOI: 10.1101/2020.09.30.321158

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