Article

Prediction and Design of Protease Enzyme Specificity Using a Structure-Aware Graph Convolutional Network

2023-02-16

Abstract excerpt

Site-specific proteolysis by the enzymatic cleavage of small linear sequence motifs is a key post-translational modification involved in physiology and disease. The ability to robustly and rapidly predict protease substrate specificity would also enable targeted proteolytic cleavage – editing – of a target protein by designed proteases. Current methods for predicting protease specificity are limited to sequence pa...

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Literature Corpus work: 83c8df88-b6b0-58a9-8973-00573cc6a07b
DOI: 10.1101/2023.02.16.528728

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