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Article

Cleavage entropy as quantitative measure of protease specificity.

PLoS computational biology - 1 Apr 2013

Fuchs Julian E, von Grafenstein Susanne, Huber Roland G, Margreiter Michael A, Spitzer Gudrun M, Wallnoefer Hannes G, Liedl Klaus R

Abstract excerpt

A purely information theory-guided approach to quantitatively characterize protease specificity is established. We calculate an entropy value for each protease subpocket based on sequences of cleaved substrates extracted from the MEROPS database. We compare our results with known subpocket specificity profiles for individual proteases and protease groups (e.g. serine proteases, metallo proteases) and reflect them...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23637583
DOI: 10.1371/journal.pcbi.1003007
PMCID: PMC3630115

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