Article

Targetable fibroblast phenotypes and EMT malignant cell states cooperate to promote tumor progression in esophageal adenocarcinoma

2023-02-13

Abstract excerpt

<h4>Background: </h4> Esophageal adenocarcinoma (EAC) is usually resistant to cytotoxic therapies and immunotherapies have gained little traction. Cancer-associated fibroblasts (CAF) are a major stromal cell population in the EAC tumor microenvironment associated with prognosis and treatment outcomes. Recent evidence suggests that cancer cell phenotypes related to EMT may determine CAF heterogeneity, but the molec...

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Literature Corpus work: 2deda1c1-71df-5c16-98e9-bb7bc1a7b3a8
DOI: 10.21203/rs.3.rs-2572575/v1

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