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Single-cell and bulk RNA analysis identifies EMT-associated CAF signatures and prognostic model in lung adenocarcinoma

14 Jun 2025

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) have gained increasing attention for their role in lung adenocarcinoma (LUAD), particularly in epithelial-mesenchymal transition (EMT), which may play a key role in tumor microenvironment remodeling and cancer progression. This study aims to identify CAF signature genes associated with EMT through the integration of single-cell RNA sequencing and bulk...

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PMID: 40517220
DOI: 10.1007/s12672-025-02951-z

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