Article
Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability.
The Journal of cell biology - 27 Feb 2006
Trinkle-Mulcahy Laura, Andersen Jens, Lam Yun Wah, Moorhead Greg, Mann Matthias, Lamond Angus I
Abstract excerpt
Protein phosphatase 1 (PP1) is a ubiquitous serine/threonine phosphatase regulating many cellular processes. PP1alpha and -gamma are closely related isoforms with distinct localization patterns, shown here by time-lapse microscopy of stably expressed fluorescent protein fusions. A pool of PP1gamma is selectively loaded onto chromatin at anaphase. Using stable isotope labeling and proteomics, we identified a novel...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
