Article

Epithelial mesenchymal transition initiates precancer states in <i>BRCA1</i> mutation carriers

2026-05-11

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) is activated to equip cells with the capacity to adapt to and escape hostile conditions. While EMT is required for cancer progression, its role in breast cancer initiation remains elusive. Given the basal-like phenotype of breast cancers arising in female carriers of germline BRCA1 pathogenic variants ( BRCA1 carriers), we hypothesized that enhanced EMT susceptibility u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2db7eda6-2761-5559-88d8-3fb4505e7e15
DOI: 10.64898/2026.05.06.723061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epithelial mesenchymal transition initiates precancer states in <i>BRCA1</i> mutation carriersDOI 10.64898/2026.05.06.723061Read

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CA <sup>H1047R</sup> oncogeneSemantic proximity Read

Signaling Pathway Alterations Driven by BRCA1 and BRCA2 Germline Mutations are Sufficient to Initiate Breast Tumorigenesis by the PIK3CAH1047R OncogeneSemantic proximity Read

Alterations in the preneoplastic breast microenvironment of <i>BRCA1/2</i> mutation carriers revealed by spatial transcriptomicsSemantic proximity Read

Cell-type-specific epigenomic variations associated with <i>BRCA1</i> mutation in pre-cancer human breast tissuesSemantic proximity Read

Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancerSemantic proximity Read

Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis.Semantic proximity Read

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesisSemantic proximity Read

Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote ControlSemantic proximity Read

BRCA1 mutation influences progesterone response in human benign mammary organoids.Semantic proximity Read

A human <i>ex vivo</i> model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic responseSemantic proximity Read

Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutationsSemantic proximity Read

Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesisSemantic proximity Read