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Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis

1 Dec 2021

Abstract excerpt

Germline pathogenic mutations in BR east CA ncer ( BRCA1 ) genes are thought to drive normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian cancer. No human models capture the sequence of events for disease initiation and progression. Here, we generate induced pluripotent stem cells (iPSCs) from healthy individuals and young ovarian cancer patients with germline pathogenic BRCA1...

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PMID: 34965417
DOI: 10.1016/j.celrep.2021.110146

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