Article
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis.
Nature genetics - 1 Apr 2023
Nee Kevin, Ma Dennis, Nguyen Quy H, Pein Maren, Pervolarakis Nicholas, Insua-Rodríguez Jacob, Gong Yanwen, Hernandez Grace, Alshetaiwi Hamad, Williams Justice, Rauf Maha, Dave Kushal Rajiv, Boyapati Keerti, Hasnain Aliza, Calderon Christian, Markaryan Anush, Edwards Robert, Lin Erin, Parajuli Ritesh, Zhou Peijie, Nie Qing, Shalabi Sundus, LaBarge Mark A, Kessenbrock Kai
Abstract excerpt
Women with germline BRCA1 mutations (BRCA1+/mut) have increased risk for hereditary breast cancer. Cancer initiation in BRCA1+/mut is associated with premalignant changes in breast epithelium; however, the role of the epithelium-associated stromal niche during BRCA1-driven tumor initiation remains unclear. Here we show that the premalignant stromal niche promotes epithelial proliferation and mutant BRCA1-driven...
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