Article

Phenotypic analysis of the CRISPR-engineered G51D α-synuclein rat

2020-01-01

Abstract excerpt

Parkinson’s disease (PD) is a common neurodegenerative disease that is most often idiopathic, but a significant proportion (5-10%) of cases are caused by highly penetrant monogenic mutations. Point mutations and multiplications of the SNCA gene, encoding α-synuclein (αSyn), are known to cause early onset aggressive familial PD. The recently described G51D mutation is particularly aggressive resulting in symptoms a...

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Literature Corpus work: 1205a775-c295-5451-899a-b0506fbd426d
DOI: 10.7488/era/191

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