Article

<i>In vivo</i> <sup>18</sup> F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation

2022-11-05

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative condition with several major hallmarks, including loss of substantia nigra neurons, reduction in striatal dopaminergic function, and formation of α-synuclein-rich Lewy bodies. Mutations in SNCA , encoding for α-synuclein, are a known cause of familial PD, and the G51D mutation causes a particularly aggressive form of the condition. CRISPR/Cas9 technology was used t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbcbcbff-8582-5516-ade8-27fa0731d5f4
DOI: 10.1101/2022.11.05.515268

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In vivo</i> <sup>18</sup> F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutationDOI 10.1101/2022.11.05.515268Read

Phenotypic analysis of the CRISPR-engineered G51D α-synuclein ratSemantic proximity Read

G51D mutation of the endogenous rat <i>Snca</i> gene disrupts synaptic localisation of α-synuclein priming for Lewy-like pathologySemantic proximity Read

G51D α‐synuclein mutation causes a novel Parkinsonian–pyramidal syndromeSemantic proximity Read

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?Semantic proximity Read

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutationSemantic proximity Read

A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old MiceSemantic proximity Read

Dopamine D2 receptor upregulation in dorsal striatum in the <i>LRRK2</i> -R1441C rat model of early Parkinson’s disease revealed by <i>in vivo</i> PET imagingSemantic proximity Read

Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice.Semantic proximity Read

PET studies of parkinsonism associated with mutation in the alpha-synuclein gene.Semantic proximity Read

Clinical and imaging findings in Parkinson disease associated with the A53E <i>SNCA</i> mutationSemantic proximity Read

Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels.Semantic proximity Read

Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation.Semantic proximity Read