Article

Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagy

2023-10-11

Abstract excerpt

Disruption of macroautophagy/autophagy has emerged as a common feature in many neurodegenerative diseases. Autophagy is a membrane-dependent pathway that requires many key regulators to quickly localize on and off membranes during induction promoting membrane fusion. Previously, our bioinformatic approaches have shown that autophagy and Huntington disease (HD) are enriched in S-acylated proteins. S-acylation invol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 942ae6e7-df2e-5fa7-9422-7efb2e15273c
DOI: 10.1101/2023.10.11.561600

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reduced S-acylation of SQSTM1/p62 in Huntington disease is associated with impaired autophagyDOI 10.1101/2023.10.11.561600Read

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.Semantic proximity Read

Atlastins mediate selective autophagy of the endoplasmic reticulumSemantic proximity Read

S-palmitoylation coordinates the trafficking of ATG9A to mediate autophagy initiationSemantic proximity Read

Absence of the Autophagy Adaptor SQSTM1/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy.Semantic proximity Read

S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis.Semantic proximity Read

SwissPalm: Protein Palmitoylation databaseSemantic proximity Read

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptomsSemantic proximity Read

α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundanceSemantic proximity Read

Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisationSemantic proximity Read

p62/ SQSTM1 and Selective Autophagy in Cardiometabolic DiseasesSemantic proximity Read

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteinsSemantic proximity Read

Fatty links between multisystem proteinopathy and Small VCP-Interacting ProteinSemantic proximity Read