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Article

Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease.

Autophagy - 2 Sept 2017

Lee YouJin, Weihl Conrad C

Abstract excerpt

Macroautophagy/autophagy can be a selective degradative process via the utilization of various autophagic receptor proteins. Autophagic receptors selectively recognize ubiquitinated cargoes and deliver them to phagophores, the precursors to autophagosomes, for their degradation. For example, SQSTM1/p62 directly binds to ubiquitinated protein aggregates via its UBA domain and sequesters them into inclusion bodies...

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Identifiers

PMID: 28812433
DOI: 10.1080/15548627.2017.1339845
PMCID: PMC5612413

Genes

SQSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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