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Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging

14 Feb 2022

Abstract excerpt

Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an essential process to maintain proteostasis. The protein Sequestosome 1 (p62/SQSTM1) is a classical selective autophagy receptor, but it also has roles in the...

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PMID: 35237597
DOI: 10.3389/fcell.2022.793328

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