Article

Genome-wide extraction of differentially methylated DNA regions using adapter-anchored proximity primers

2025-06-30

Abstract excerpt

The epigenetic deregulation of CpG islands (CGIs) plays a crucial role in cancer initiation and progression. CGIs comprise 1-2% of the human genome and are rich in differentially methylated regions (DMRs) that can serve as cancer biomarkers in clinical samples and liquid biopsies. Focusing epigenetic sequencing on CpG-rich sequences, including CGIs and avoiding non-informative regions, offers an efficient and sens...

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Literature Corpus work: 2dac16cd-b4ad-59d0-a49e-afb43a894558
DOI: 10.1101/2025.06.29.660377

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