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Article

Methylation-sensitive enrichment of minor DNA alleles using a double-strand DNA-specific nuclease.

Nucleic acids research - 7 Apr 2017

Liu Yibin, Song Chen, Ladas Ioannis, Fitarelli-Kiehl Mariana, Makrigiorgos G Mike

Abstract excerpt

Aberrant methylation changes, often present in a minor allelic fraction in clinical samples such as plasma-circulating DNA (cfDNA), are potentially powerful prognostic and predictive biomarkers in human disease including cancer. We report on a novel, highly-multiplexed approach to facilitate analysis of clinically useful methylation changes in minor DNA populations. Methylation Specific Nuclease-assisted...

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Identifiers

PMID: 27903892
DOI: 10.1093/nar/gkw1166
PMCID: PMC5389605

Genes

ATM
GSTP1
MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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