Article

A Robust Targeted Sequencing Approach for Low Input and Variable Quality DNA from Clinical Samples

2017-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Next-generation deep sequencing of gene panels is being adopted as a diagnostic test to identify actionable mutations in cancer patient samples. However, clinical samples, such as formalin-fixed, paraffin-embedded specimens, frequently provide low quantities of degraded, poor quality DNA. To overcome these issues, many sequencing assays rely on extensive PCR amplification leading to an accumulat...

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Literature Corpus work: 08be14b4-559d-5f5c-82fe-fe1c11a471ca
DOI: 10.1101/123117

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