Article

Diverse and weakly immunogenic<i>var</i>gene expression facilitates malaria infection

2024-01-02

Abstract excerpt

Plasmodium falciparum is believed to escape immunity via antigenic variation, mediated in part by 60 var genes. These genes undergo mutually exclusive expression and encode the PfEMP1 surface antigen. The frequency of var switching and the immunogenicity of each expressed PfEMP1 remain unclear. To this end, we carried out a Controlled Human Malaria Infection (CHMI) study with 19 adult African volunteers in The Gam...

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Literature Corpus work: 2d9ff7d2-d064-5c29-a11e-a89056d5c9b1
DOI: 10.1101/2023.12.27.23300577

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