Article
Expressed var gene repertoire and variant surface antigen diversity in a shrinking Plasmodium falciparum population.
Experimental parasitology - 1 Nov 2016
Carlos Bianca C, Fotoran Wesley L, Menezes Maria J, Cabral Fernanda J, Bastos Marcele F, Costa Fabio T M, Sousa-Neto Jayme A, Ribolla Paulo E M, Wunderlich Gerhard, Ferreira Marcelo U
Abstract excerpt
The var gene-encoded erythrocyte membrane protein-1 of Plasmodium falciparum (PfEMP-1) is the main variant surface antigen (VSA) expressed on infected erythrocytes. The rate at which antibody responses to VSA expressed by circulating parasites are acquired depends on the size of the local VSA repertoire and the frequency of exposure to new VSA. Because parasites from areas with declining malaria endemicity, such...
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