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Article

Diverse outcomes of controlled human malaria infection originate from host-intrinsic immune variation and not <i>var</i> gene switching

2020-09-07

Abstract excerpt

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variation observed in controlled human malaria infection (CHMI). We uncovered marked heterogeneity in the response of naive...

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Identifiers and source

Literature Corpus work
37f5282b-1f82-51c3-bea0-84362dc772ba
DOI
10.1101/2020.09.04.20188144
Open publication

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Diverse outcomes of controlled human malaria infection originate from host-intrinsic immune variation and not <i>var</i> gene switchingDOI 10.1101/2020.09.04.20188144
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