Article

Distinct evolutionary patterns of tumor immune escape and elimination determined by ECM architectures

2024-05-15

Abstract excerpt

Cancer progression remains a significant clinical challenge. Phenotypic adaptation by tumor cells results in disease hetero-geneity, which drives treatment resistance and immune escape. T cell immunotherapy, while effective at treating some cancer subtypes, can also fail due to limits on tumor immunogenicity or T cell recognition. For example, one potential contributor to immune escape involves the density and ali...

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Literature Corpus work: 2d9f58c4-e1a7-5ac5-8ed6-23da278bbb1a
DOI: 10.1101/2024.05.13.594017

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